Last Saturday saw it become three defeats in a row for the Gingerbreads as they fell to a 1-0 defeat at home in horrendous conditions to a play-off chasing Buxton.
With only seven games of the season left, Grantham dropped to 18th but still remain six points clear of Mickleover Sports who occupy the final relegation spot.
Paul Rawden's men will also look to leave an unwanted record behind having not picked up a point on the road so far since Rawden and Russ Cousins took the managerial reigns.
Nantwich Town are looking to cement their play-off position, and were involved in an enterprising game last weekend, sharing eight goals in a 4-4 draw away at Hednesford Town.
Despite being nine points behind leaders Farsley Celtic, the Dabbers are in fourth place, and eight points clear of Scarborough Athletic who look to sneak into the play-off places.
It was victory for the Dabbers in the earlier meeting this season as Nantwich came away from the Meres with all three points in a thrilling 3-2 victory in October, which was Ian Culverhouse's last game in charge.
Grantham boss Paul Rawden says the games are running out for his team and he wants them to be as safe as possible: "I think it is safe to say we have hit a bit of a sticky patch after a really good start.
"We don't have long left in the season now so it is vital that we make every game count from now until the end of the season by creating chances and taking them when they arrive."
Rawden said he will also look to the experience of his older players to help in the fight for survival: "We have lots of experience throughout the core of this squad and that could play a huge part in our fight.
We have a good mix of youth and experience and those older players can help the younger ones as they have done it before. We must remain calm but at the same time we must make sure we are picking up points - especially when other teams have the ability to drop points around us too."
Midfielder Callum Coyle joined on loan from Vanarama National League outfit Solihull Moors in the week and could play a role this weekend as well as experienced striker Shane Benjamin, who signed from Hednesford Town on Thursday night.
Sam Cartwright will miss the next two weeks due to a foot injury, but Connor Bartle returns after missing last week's match. There are no new injury concerns for this weekend's fixture.
Tom Ward has been doing extra yoga classes and has declared himself fully fit for the weekend.
Castlegate Financial Management are Independent Financial Advisers working within the Duncan & Toplis group, specialising in investment advice and retirement planning, operating in Grantham, Lincoln and the wider Midlands. They can be contacted on 01476 591022 or visit their website www.casfin.co.uk