The Gingerbreads were unable to follow up there impressive victory against South Shields last Saturday as they fell to a 2-1 defeat away at Whitby Town.
Two quick-fire goals from corners gave the Seasiders a 2-0 lead going into half time on the North Yorkshire coast before Ross Barrows replied with a thunderous effort to reduce the deficit.
Despite a late onslaught from the Gingerbreads, the home side were able to hold on and consign joint managers Paul Rawden and Russ Cousins to their first defeat since taking over.
Although the Gingerbreads came back with no points, they still remain in 16th place and six points clear of the relegation zone.
Opponents Matlock travel from Derbyshire with just one win from their last five.
Likewise to the Gingerbreads, the visitors also came unstuck last weekend - losing 2-1 at home to title chasing Farlsey Celtic to leave Dave Frecklington's men in 10th position.
Grantham boss Rawden believes his side are improving all the time and that they learnt a lot from last weekend's defeat ahead of Saturday's fixture: "Although we lost last weekend, I think the lads learnt a lot and that will stand them in good stead for the long term.
"The second half was the sort of football we like to see and for me and Russ its clear to see they are improving all the time.
"Matlock are a good side and will pose threats but we have our own threats and especially being at home, we will take the game to them and cause them problems."
Rawden also spoke of the return of Chris Salt and Michael Hollingsworth and said that his squad can't dwell about friendships on the pitch: "Obviously with any return of players to former clubs you'll hope the fans give them a good reception for what they did but whilst my players are on the pitch they need to forget about friendships and try and get the win for the team.
"The team has a job to do and I am confident that they can go out and get what would be a very important win in the relegation battle we're in."
Tom Ward is fully fit after his recent injury and is ready to play, whilst the rest of the squad remains available for selection.
In squad news, Danny Durkin has joined Barwell on loan until the end of the season.
Charlie Ward has left the club and we wish Charlie well and thank him for his contribution.
Sam Cartwright joins on loan for the rest of the season from Peterborough United. The defender has been on loan at St Ives this season but was recalled by then boss Steve Evans.
Ashanti Pryce has also joined from Hednesford. The Striker started the season at Bromsgrove Sporting, and was previously on the books of Mansfield Town.
Castlegate Financial Management are Independent Financial Advisers working within the Duncan & Toplis group, specialising in investment advice and retirement planning, operating in Grantham, Lincoln and the wider Midlands. They can be contacted on 01476 591022 or visit their website www.casfin.co.uk